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Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

Data from the innervation of intact mice hearts and the mapping of parasympathetic and sympathetic neural circuits which control heart rate. This data set identifies the cholinergic and noradrenergic neurons which project to the sinoatrial node.
57 Files
14.27 GB
25 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Pradeep Rajendran updated on October 20, 2020
noradrenergic, mus musculus, cardiac autonomic nervous system + More
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A multi-scale model of cardiac electrophysiology

A workflow containing differential equation models of cardiac physiology that automate the execution of simulations with user defined options of outputs from a single cell, 1 or 2-Dimensional tissue, and a pseudo-ECG output.
224 Files
8.22 MB
5 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Colleen Clancy updated on October 19, 2020
pseudo-ecg, action potential, cardiac electrophysiology + More
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Morphometric analysis of the abdominal vagus nerve in rats

Determination of light and electron microscopy characteristics of the abdominal vagus nerve in rats.
85 Files
1.14 GB
57 Records
CC-BY-4.0
Natalia Biscola updated on October 1, 2020
electron microscopy, rattus norvegicus, abdominal vagus nerve + More
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Quantified Morphology of the Pig Vagus Nerve

Binary traces from segmentation of cross sections of cervical and subdiaphragmatic pig vagus nerves stained with Masson's trichrome. Quantified effective nerve diameter, effective fascicle diameter, and number of fascicles.
165 Files
968.01 MB
39 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Nicole Pelot updated on October 1, 2020
vagus nerve stimulation, vagus nerve morphology, autonomic nervous system + More
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Quantified Morphology of the Human Vagus Nerve with Anti-Claudin-1

Immunohistochemistry micrographs of human vagus nerves labeled with anti-claudin-1. Binary traces from segmentation to quantify effective nerve diameter, effective fascicle diameter, number of fascicles, and perineurium thickness.
243 Files
2.76 GB
47 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Nicole Pelot updated on October 1, 2020
vagus nerve stimulation, homo sapiens, human + More
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Human Vagus Nerve Stained with Masson's Trichrome

Micrographs of cross sections of cervical and abdominal human vagus nerve stained with Masson's trichrome.
312 Files
13.63 GB
113 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Nicole Pelot updated on October 1, 2020
vagus nerve stimulation, autonomic nervous system, vagus nerve morphology + More
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Quantified Morphology of the Rat Vagus Nerve

Binary traces from segmentation of cross sections of cervical and subdiaphragmatic rat vagus nerves stained with Masson's trichrome. Quantified effective nerve diameter, effective fascicle diameter, number of fascicles, and perineurium thickness.
149 Files
205.98 MB
40 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Nicole Pelot updated on October 1, 2020
rattus norvegicus, vagus nerve stimulation, vagus nerve morphology + More
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Quantified Morphology of the Pig Vagus Nerve with Anti-Fibronectin

Immunofluorescence micrographs of pig vagus nerves labeled with anti-fibronectin. Binary traces from segmentation to quantify effective nerve diameter, effective fascicle diameter, number of fascicles, and perineurium thickness.
162 Files
7.61 GB
42 Records
CC-BY-4.0
Nicole Pelot updated on October 1, 2020
vagus nerve stimulation, autonomic nervous system, vagus nerve morphology + More
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Immediate Early Gene (IEG) mapping of spinal cord neurons activated by cystometry induced micturition in rat

Spatial mapping of cystometry-activated neurons in the sacral spinal cord in awake male and female rats.
2,621 Files
104.13 GB
109 Records
CC-BY-4.0
Janet Keast updated on September 30, 2020
rattus norvegicus, sacral spinal cord, urinary bladder + More
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Distribution of Nitregic Cholinergic and all MP Neurons

Contains source data and reconstructed images of nNOS, cholinergic and glial distribution in the murine large intestine.
186 Files
410.22 GB
79 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Thomas Gould updated on September 30, 2020
myenteric plexus, neuron distribution, murine enterice nervous system + More
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Excitation Properties of Computational Models of Unmyelinated Peripheral Axons

Data and plotting code for excitation responses of multiple single compartment and multi-compartment models of peripheral unmyelinated axons
1,999 Files
962.77 MB
6 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Nicole Pelot updated on September 25, 2020
unmyelinated axon, voltage-gated ion channels, vagus nerve + More
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Scientific Articles

A collection of relevant articles around Bioelectronic medicine, Biomarkers and digital health care
36 Files
34.59 MB
No Records
CC-BY-SA-4.0
Dataset will be released on September 24, 2021
articles, books
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Comparison of the Intrinsic Cardiac Nervous System Across Male and Female Rat Hearts

Single neurons were mapped and cardiac anatomy was annotated in image volumes of male and female rat hearts to compare the intrinsic cardiac nervous system between individuals and across sexes.
77 Files
439.79 GB
37 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Clara Leung updated on September 17, 2020
rat intrinsic cardiac neurons, knife edge scanning microscopy, 3d heart reconstructions + More
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Anatomy and Histology of the Domestic Pig in the Context of Vagus Nerve Stimulation

Incorporation of Motor Efferent Branches of Vagus into VNS Activation
2,700 Files
232.07 GB
943 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Kip Ludwig updated on September 8, 2020
vagotopy, electroceuticals, vagus nerve stimulation + More
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Neurofauna Rat

This detailed anatomical representation of a rat that can be viewed and explored in a 3D viewer.
6 Files
39.74 KB
No Records
MIT

Sponsored by

NIH SPARC Program

Ignacio Pascual updated on August 27, 2020
rat, pns, heart + More
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Human Islet Microvasculature Analysis

Human pancreas cleared with passive CLARITY, immunostained, and imaged on a Zeiss 710 microscope. Image analysis of islet and islet collagen IV volumes were determined using Vesselucida360.
128 Files
30.13 GB
53 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Martha Campbell-Thompson updated on August 24, 2020
pancreas, confocal image, microvasculature + More
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Characterizing the effect of feeding distension and emetic stimuli on gastric myoelectric activity in ferrets

This dataset contains gastric myoelectric activity recorded from multi-electrode arrays, surgically implanted on the serosal surface of the GI tract to study perturbations due to mechanical or chemical stimuli in acute and chronic preparations of ferrets
20,315 Files
364.42 GB
20,354 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Charles Horn updated on August 24, 2020
nausea, ferret, electrogastrogram + More
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Mapping of ICN Neurons in a 3D Reconstructed Rat Heart

Single intrinsic cardiac nervous system (ICN) neurons were marked in an image volume of heart sections that was anatomically delineated for the 3D reconstruction of the whole heart with mapped locations of individual ICN neurons.
23 Files
55.71 GB
19 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Clara Leung updated on August 4, 2020
rattus norvegicus, knife edge scanning microscopy, rodent cardiac anatomy + More
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Rat Vagus Nerve Stained with Masson's Trichrome

Micrographs of cross sections of cervical and abdominal rat vagus nerve stained with Masson's trichrome.
163 Files
2.76 GB
52 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Nicole Pelot updated on August 4, 2020
vagus nerve stimulation, rattus norvegicus, autonomic nervous system + More
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Generic mouse colon scaffold

Annotated mouse colon scaffold available for registration of segmented neural anatomical-functional mapping of enteric neural circuits.
28 Files
3.85 MB
4 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Mabelle Lin updated on July 17, 2020
mesenteric zone, colon, mouse
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Pig Vagus Nerve Stained with Masson's Trichrome

Micrographs of cross sections of cervical and abdominal pig vagus nerve stained with Masson's trichrome.
160 Files
5.04 GB
70 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Nicole Pelot updated on July 16, 2020
vagus nerve stimulation, autonomic nervous system, vagus nerve morphology + More
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Compound action potential integrated use case example

An example dataset of a vagus nerve compound action potential for use in demonstrating the integration between the various components of the SPARC DRC. This dataset is only intended for use in demonstrations.
9 Files
129.2 KB
2 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

David Nickerson updated on June 3, 2020
vagus nerve
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Real-time particle-by-particle detection of erythrocyte camouflaged microsensor with extended circulation time in the bloodstream

Raw data of sensor response measured in vitro (plate reader, flow cytometer, DiFC) and in vivo (DiFC)
410 Files
7.76 GB
No Records
CC-BY-4.0
Isen Andrew Calderon updated on May 29, 2020
optode sensor, in vivo flow cytometer, sodium sensing + More
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Kember Cardiac Nerve Model

Simulation and viewer for a model of autonomic control of cardiac function contributed by Prof. Guy Kember from Dalhousie University. Caption: A schematic of the mathematical model for closed-loop, networked cardiac regulation
6 Files
62.93 KB
No Records
MIT

Sponsored by

NIH SPARC Program

Katie Zhuang updated on May 28, 2020
heart, myocardial infarction, autonomic
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Functional recordings from the pig intrinsic cardiac nervous system (ICN)

Pigs monitored for ICN recoding via cardiovascular output monitoring after cervical vagi stimulation.
26 Files
1.08 GB
21 Records
CC-BY-4.0

Sponsored by

NIH SPARC Program

Jeffrey Ardell updated on May 19, 2020
sus scrofa domesticus, cardiac icn, vagus + More
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