A computational workflow for integration and implementation of a reusable and reproducible human cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue
The workflow integrates multistep single-cell, 1D and 2D model simulations in a single automated process. The model formulation for ventricular cells from humans (Grandi-Bers*) are implemented in the workflow. The model contains beta-adrenergic signaling pathways, and the firing rate model (unpublished Lewis model).
*Grandi, E., Pasqualini, F. S., & Bers, D. M. (2010). A novel computational model of the human ventricular action potential and Ca transient. Journal of molecular and cellular cardiology, 48(1), 112-121.
This work is also based on previous research using Kepler flows to model cardiac physiology: https://data.sparc.science/browse/#/datasets/23