Multi-scale human cardiac electrophysiology models

A computational workflow for integration and implementation of a reusable and reproducible human cardiac multi-scale electrophysiology model. Caption: Illustration of ion channels and action potential propogation in cardiac tissue

Updated on August 14, 2019 (Version 9)
Pei-Chi Yang , Colleen E. Clancy, Timothy J. Lewis, Mao-Tsuen Jeng
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Multi-scale human cardiac electrophysiology models

The workflow integrates multistep single-cell, 1D and 2D model simulations in a single automated process. The model formulation for ventricular cells from humans (Grandi-Bers*) are implemented in the workflow. The model contains beta-adrenergic signaling pathways, and the firing rate model (unpublished Lewis model).


*Grandi, E., Pasqualini, F. S., & Bers, D. M. (2010). A novel computational model of the human ventricular action potential and Ca transient. Journal of molecular and cellular cardiology, 48(1), 112-121.

This work is also based on previous research using Kepler flows to model cardiac physiology:

About this dataset

Publishing history

August 14, 2019
Originally Published
August 14, 2019 (Version 9)
Last Updated

Cite this dataset

Pei-Chi Yang, Clancy, C. E., Lewis, T. J., & Mao-Tsuen Jeng. (2019). Multi-scale human cardiac electrophysiology models [Data set]. Blackfynn.