Characterizing the effect of feeding distension and emetic stimuli on gastric myoelectric activity in ferrets

Ameya Nanivadekar
Charles Horn

This dataset contains gastric myoelectric activity recorded from multi-electrode arrays, surgically implanted on the serosal surface of the GI tract to study perturbations due to mechanical or chemical stimuli in acute and chronic preparations of ferrets

Updated on September 25, 2019 (Version 1)

Corresponding Contributor:

Ameya Nanivadekar
Dataset Banner Image
20,285 Files
364.41 GB
20,332 Records

Dataset Overview

Although electrogastrography (EGG) could be a critical tool in the diagnosis of patients with gastrointestinal (GI) disease, it remains under-utilized. The lack of spatial and temporal resolution using current EGG methods presents a significant roadblock to more widespread usage. Human and preclinical studies have shown that GI myoelectric electrodes can record signals containing significantly more information than can be derived from abdominal surface electrodes. The current study sought to assess the efficacy of multi-electrode arrays, surgically implanted on the serosal surface of the GI tract, from gastric fundus-to-duodenum, in recording myoelectric signals. It also examines the potential for machine learning algorithms to predict functional states, such as retching and emesis, from GI signal features. Studies were performed using ferrets, a gold standard model for emesis testing. Our results include simultaneous recordings from up to six GI recording sites in both anesthetized and chronically implanted free-moving ferrets. Testing conditions to produce different gastric states included gastric distension, intragastric infusion of emetine (a prototypical emetic agent), and feeding. Despite the observed variability in GI signals, machine learning algorithms, including k-nearest neighbors and support vector machines, were able to detect the state of the stomach with high overall accuracy (>80%). The present study is the first demonstration of machine learning algorithms to detect the physiological state of the stomach and onset of retching, which could provide a methodology to diagnosis GI diseases and symptoms such as nausea and vomiting.

Files

Gastric myoelectric data are organized based on the experiment type (GMA-acute or GMA-chronic). As detailed in the associated paper, several montages were used while analyzing GMA. Data for each montage are stored in the following subfolders:

  • GMA-bipolar - bipolar difference of individual paddle electrode contacts
  • GMA-bipolarPaddleAvg - bipolar difference of paddle averaged signals
  • GMA-CommonAvg - average of all recorded channels
  • GMA-PaddleAvg - average of all channels on each paddle
  • GMA-raw - raw single ended recording per channel

Models and Records

Models were created for each GMA type, trial type and subject. GMA models contain links to the respective data files. Subject models contain metadata for each animal. Trial models correspond to the following trial types:

  • Trial-rec - quiet recording baseline trials for acute experiments
  • Trial-balloon - balloon distension trials for acute experiments
  • Trial-emetine - emetine infusion trials for acute experiments
  • Trial-rec_awake - awake recording trials for chronic experiments
  • Trial-feeding - feeding trials for chronic experiments
  • Trial-post_feeding - post-feeding recording trials in chronic experiments
  • Trial-pre_feeding - pre-feeding recording trials in chronic experiments
  • Trial-emetine_awake - emetine infusion trials in chronic experiments
  • Trial-water_awake - water infusion/distension trials in chronic experiments

Files

Root Directory

1 - 5 of 5 files

File Name
Type
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banner.jpg
JPEG
153.92 KB
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metadata.json
Json
4.78 MB
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readme.md
Markdown
3.1 KB

About this dataset

Publishing history

September 25, 2019
Originally Published
October 17, 2019 (Version 1)
Last Updated

Cite this dataset

Ameya Nanivadekar, Derek Miller, Stephanie Fulton, Bill Yates, Lee Fisher, & Charles Horn. (n.d.). Characterizing the effect of feeding distension and emetic stimuli on gastric myoelectric activity in ferrets. Blackfynn. https://doi.org/10.26275/8ZGA-GPKD