The goal of this work is to evaluate laterality of vagus nerve efference evoked by unilateral auricular branch of the vagus nerve (ABVN) stimulation using bilateral recordings of cervical vagus nerve activity (CVNA). [Napadow, MGH]
Study Purpose: The goal of this work is to evaluate laterality of vagus nerve efferents evoked by unilateral auricular branch of the vagus nerve (ABVN) stimulation by performing bilateral recordings of cervical vagus nerve activity (CVNA).
Data Collected: ABVN stimulation protocol was as follows: three 0.5mA trains of stimulation (1Hz, 0.5ms) repeated at every 5min followed by three 1mA trains of stimulation (1Hz, 0.5ms) repeated at every 5 min. Parameters for ABVN stimulation included a series of 5 stimulus pulse trains, with each pulse consisting of a 0.5 mA current intensity, 0.5 ms pulse width, and delivered at a frequency of 20Hz.
Primary Conclusion: None stated
Experimental design: Animals were anesthetized and cervical vagus nerve activity was recorded using hook electrodes from the right and/or left cervical vagus nerve in response to left auricular vagus nerve stimulation. There is a single group of animals.
Completeness: This dataset is complete.
Subjects & Samples: Four female and five male Wistar rats, 10-12 weeks old, asserted to be adults
Primary vs derivative data: The raw data is formatted as ADInstrument compound files, which can be read by using the free LabChart Reader software. This software will need to be downloaded and it is currently available for windows and mac. This is a proprietary format, but it does contain some settings information as metadata. Each of the raw files is large and will open in a text editor, but may crash your computer.
Open question: From the file named longsheet (in the documents folder) describing the experiments conducted in more detail it appears that subjects 1002 and 1006, a male and a female rat, have usable data that passed investigators quality control. Most of the other subjects had errors reported including saturated responses or unusable data. It may be instructive to remove these subjects from this dataset in reanalysis.
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