Functional neuronal nodose recording from pig- Modulation by myocardial ischemia and variably coupled PVC's

Marmar Vaseghi
,
Siamak Salavtion
,
Naoko Yamagochi
,
Jonathon Hoang

Linear micro electrode recordings of in vivo pig nodose ganglia cardiac neurons identified with cardiovascular interventions including ischemia and PVC's to determine effects on vagal afferent neurotransmission.

Updated on May 9, 2020 (Version 1, Revision 1)

Corresponding Contributor:

scott john
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Dataset Overview

Study purpose: The purpose of this study was to evaluate the effects of premature ventricular contractions, PVCs, on vagal afferent neurotransmission and compare these effects with a known powerful autonomic modulator, myocardial ischemia.

Data collection: In vivo neuronal recordings were taken from pig nodose ganglion, with custom made linear 16 channel microelectrodes. Cardiac neurons were identified based on their response to cardiovascular interventions, including ventricular chemical and mechanical stimuli, left anterior descending (LAD) coronary artery occlusion, and variably coupled premature ventricular contractions, PVCs.

Primary conclusion: Both chemosensitive and mechanosensitive neurons were activated by PVC's, with activity remaining elevated even after PVC cessation. Cardiac neural responses to PVC were greater than any other intervention- including ischemia of a similar duration. Data suggests that even brief PVC's modulate vagal efferent neurotransmission, reflexively decreasing parasympathetic efferent tone.


Curator's Notes

Experimental Design: In 10 pigs, direct nodose neuronal recordings were obtained in vivo. The sensitivity of nodose ganglion neurons to the following types of stimulation was compared: chemical stimulation, mechanical stimulation, arterial occlusion, and premature ventricular contractions.

Completeness: Complete

Subjects/Samples: 9 pigs between 3 to 5 months of age. For 2 pigs, the age was unknown. The group was composed of 3 female subjects and 6 male subjects.

Primary vs. Derived: Data for each subject is presented as a .smrx file. There is no derivatives folder.

Important Notes: Published at doi:10.1152/ajpheart.00286.2019. A copy of the publication can be found in the docs folder. Of the 16 animals studied only nine animals, included in the dataset, showed identification of cardiac neurons in the nodose ganglion. In seven animals cardiac neurons could not be identified in the nodose ganglion and therefore were excluded from the dataset.

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Publishing history

February 28, 2020
Originally Published
May 9, 2020 (Version 1)
Last Updated

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